Salen Capsules / Topical Solution (Methoxsalen Capsules U.S.P. Methoxsalen Topical Solution U.S.P. 1% w/v) Back
Composition: Salen Capsules
Each hard gelatin capsule contains
Methoxsalen U.S.P 10 mg
Excipients q.s.
Color Approved colour used in Empty Capsule Shell
Composition: Salen Topical Solution
Methoxsalen U.S.P. 1% w/v
Non-Aqueous Base q.s.
Indications:
- Vitiligo
- Psoriasis
- Atopic Dermatitis
Description:
- Methoxasalen the most effective psoralen derivative used in vitiligo and psoriasis, which acts as photosensitizer. Works by making the skin more sensitive to UVA light
- Most common recommended treatment for vitiligo is methoxsalen followed by exposure to solar radiation or UVA radiation
Application:
As directed by the physician
Dosage Guidelines:
Vitiligo Theraphy
Drug Dosage: Two capsules (10 mg each) in one dose taken with milk or in food two to four hours before ultraviolet light exposure.
Light Exposure: The exposure time to sunlight should comply with the following guide:
Basic Skin Color Light Medium Dark
Initial Exposure 15 min 20 min 25 min
Second Exposure 20 min 25 min 30 min
Third Exposure 25 min 30 min 35 min
Fourth Exposure 30 min 35 min 40 min
Subsequent Exposure: Gradually increase exposure based on erythema and tenderness of the amelanotic skin.Therapy should be on alternate days and never two consecutive days.
Psoriasis Theraphy
Drug Dosage - Initial Theraphy: The methoxsalen capsules should be taken 2 hours before UVA exposure with some food or milk according to the following table:
Patient's Weight Dose
(kg) (lbs.) (mg)
<30 <66 10
30-50 66-110 20
51-65 112-143 30
66-80 146-176 40
81-90 179-198 50
91-115 201-254 60
>115 >254 70
Additional drug dosage directions are as follows:
- Weight Change: In the event that the weight of a patient changes during treatment such that he/she falls into an adjacent weight range/dose category, no change in the dose of methoxsalen is usually required. If, in the physician's opinion, however, a weight change is sufficiently great to modify the drug dose, then an adjustment in the time of exposure to UVA should be made
- Dose/Week: The number of doses per week of methoxsalen capsules will be determined by the patient's schedule of UVA exposures. In no case should treatments be given more often than once every other day because the full extent of phototoxic reactions may not be evident until 48 hours after each exposure
- Dosage Increase: Dosage may be increased by 10 mgm after the fifteenth treatment
Presentation:
Salen Topical Solution – 25 ml bottle
Salen Capsules – 3 X 10 capsules
Note: To be used only on the advice of a Registered Medical Practitioner.
